Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.
Identifieur interne : 001259 ( Main/Exploration ); précédent : 001258; suivant : 001260Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.
Auteurs : Alessandra Vultaggio [Italie] ; Ioana Agache [Roumanie] ; Cezmi A. Akdis [Suisse] ; Mubeccel Akdis [Suisse] ; Sevim Bavbek [Turquie] ; Apostolos Bossios [Suède] ; Jean Bousquet (allergologue) [Allemagne, France] ; Onur Boyman [Suisse] ; Adam M. Chaker [Allemagne] ; Susan Chan [Royaume-Uni] ; Alexia Chatzipetrou [Grèce] ; Wojciech Feleszko [Pologne] ; Davide Firinu [Italie] ; Marek Jutel [Pologne] ; Paula Kauppi [Finlande] ; Ludger Klimek [Allemagne] ; Antonios Kolios [France, Suisse, États-Unis] ; Akash Kothari [Canada] ; Marek L. Kowalski [Pologne] ; Andrea Matucci [Italie] ; Oscar Palomares [Espagne] ; Oliver Pfaar [Allemagne] ; Barbara Rogala [Pologne] ; Eva Untersmayr [Autriche] ; Thomas Eiwegger [Canada]Source :
- Allergy [ 1398-9995 ] ; 2020.
Abstract
The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a "cytokine storm" and associated organ damage characterized by an exaggerated release of proinflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19 with studies focusing on severe allergic phenotypes lacking. At present, non-infected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management is demanded.
DOI: 10.1111/all.14407
PubMed: 32500526
PubMed Central: PMC7300800
Affiliations:
- Allemagne, Autriche, Canada, Espagne, Finlande, France, Grèce, Italie, Pologne, Roumanie, Royaume-Uni, Suisse, Suède, Turquie, États-Unis
- Angleterre, Attique (région), Bavière, Berlin, Canton de Zurich, Communauté de Madrid, District de Giessen, District de Haute-Bavière, Grand Londres, Hesse (Land), Languedoc-Roussillon, Massachusetts, Occitanie (région administrative), Ontario, Svealand, Vienne (Autriche)
- Athènes, Berlin, Londres, Madrid, Marbourg, Montpellier, Munich, Stockholm, Toronto, Vienne (Autriche), Zurich
- Centre hospitalier universitaire de Montpellier, Université Louis-et-Maximilien de Munich, Université de Montpellier, Université de Toronto, Université de Zurich
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Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Chaker, Adam M" sort="Chaker, Adam M" uniqKey="Chaker A" first="Adam M" last="Chaker">Adam M. Chaker</name><affiliation wicri:level="4"><nlm:affiliation>Technical University of Munich, TUM School of Medicine, Klinikumrechts der Isar, Department of Otolaryngology and Center for Allergy and Environment, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University of Munich, TUM School of Medicine, Klinikumrechts der Isar, Department of Otolaryngology and Center for Allergy and Environment, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Chan, Susan" sort="Chan, Susan" uniqKey="Chan S" first="Susan" last="Chan">Susan Chan</name><affiliation wicri:level="3"><nlm:affiliation>Guy's and St, Thomas' NHS Foundation Trust, Westminster Bridge Road, London, United KingdomKing's, College LondonSchool of Life Course Sciences & School of Immunology & Microbial Sciences, King's Health Partners, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy's and St, Thomas' NHS Foundation Trust, Westminster Bridge Road, London, United KingdomKing's, College LondonSchool of Life Course Sciences & School of Immunology & Microbial Sciences, King's Health Partners, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatzipetrou, Alexia" sort="Chatzipetrou, Alexia" uniqKey="Chatzipetrou A" first="Alexia" last="Chatzipetrou">Alexia Chatzipetrou</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit 2, nd Department of Dermatology and Venereology, National University of Athens, Medical School, University General Hospital 'ATTIKON", Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Allergy Unit 2, nd Department of Dermatology and Venereology, National University of Athens, Medical School, University General Hospital 'ATTIKON", Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Feleszko, Wojciech" sort="Feleszko, Wojciech" uniqKey="Feleszko W" first="Wojciech" last="Feleszko">Wojciech Feleszko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Firinu, Davide" sort="Firinu, Davide" uniqKey="Firinu D" first="Davide" last="Firinu">Davide Firinu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences and Public Health, University of Cagliari, Monserrato</wicri:regionArea><wicri:noRegion>Monserrato</wicri:noRegion></affiliation></author><author><name sortKey="Jutel, Marek" sort="Jutel, Marek" uniqKey="Jutel M" first="Marek" last="Jutel">Marek Jutel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Wroclaw Medical University, ALL-MED Medical Research Institute, Wrocław, Poland, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, Wroclaw Medical University, ALL-MED Medical Research Institute, Wrocław, Poland, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Kauppi, Paula" sort="Kauppi, Paula" uniqKey="Kauppi P" first="Paula" last="Kauppi">Paula Kauppi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Klimek, Ludger" sort="Klimek, Ludger" uniqKey="Klimek L" first="Ludger" last="Klimek">Ludger Klimek</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Rhinology and Allergy, Wiesbaden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Rhinology and Allergy, Wiesbaden</wicri:regionArea><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion></affiliation></author><author><name sortKey="Kolios, Antonios" sort="Kolios, Antonios" uniqKey="Kolios A" first="Antonios" last="Kolios">Antonios Kolios</name><affiliation wicri:level="3"><nlm:affiliation>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Immunology, University Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kothari, Akash" sort="Kothari, Akash" uniqKey="Kothari A" first="Akash" last="Kothari">Akash Kothari</name><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kowalski, Marek L" sort="Kowalski, Marek L" uniqKey="Kowalski M" first="Marek L" last="Kowalski">Marek L. Kowalski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Immunology and Allergy, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Matucci, Andrea" sort="Matucci, Andrea" uniqKey="Matucci A" first="Andrea" last="Matucci">Andrea Matucci</name><affiliation wicri:level="1"><nlm:affiliation>Immunoallergology Unit, Careggi University Hospital, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Immunoallergology Unit, Careggi University Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palomares, Oscar" sort="Palomares, Oscar" uniqKey="Palomares O" first="Oscar" last="Palomares">Oscar Palomares</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pfaar, Oliver" sort="Pfaar, Oliver" uniqKey="Pfaar O" first="Oliver" last="Pfaar">Oliver Pfaar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Rogala, Barbara" sort="Rogala, Barbara" uniqKey="Rogala B" first="Barbara" last="Rogala">Barbara Rogala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Untersmayr, Eva" sort="Untersmayr, Eva" uniqKey="Untersmayr E" first="Eva" last="Untersmayr">Eva Untersmayr</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Eiwegger, Thomas" sort="Eiwegger, Thomas" uniqKey="Eiwegger T" first="Thomas" last="Eiwegger">Thomas Eiwegger</name><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Immunology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32500526</idno><idno type="pmid">32500526</idno><idno type="doi">10.1111/all.14407</idno><idno type="pmc">PMC7300800</idno><idno type="wicri:Area/Main/Corpus">000F49</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F49</idno><idno type="wicri:Area/Main/Curation">000F49</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000F49</idno><idno type="wicri:Area/Main/Exploration">000F49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.</title><author><name sortKey="Vultaggio, Alessandra" sort="Vultaggio, Alessandra" uniqKey="Vultaggio A" first="Alessandra" last="Vultaggio">Alessandra Vultaggio</name><affiliation wicri:level="1"><nlm:affiliation>Immunoallergology Unit, Careggi University Hospital, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Immunoallergology Unit, Careggi University Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Agache, Ioana" sort="Agache, Ioana" uniqKey="Agache I" first="Ioana" last="Agache">Ioana Agache</name><affiliation wicri:level="1"><nlm:affiliation>Transylvania University, Brasov, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Transylvania University, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Akdis, Cezmi A" sort="Akdis, Cezmi A" uniqKey="Akdis C" first="Cezmi A" last="Akdis">Cezmi A. Akdis</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Akdis, Mubeccel" sort="Akdis, Mubeccel" uniqKey="Akdis M" first="Mubeccel" last="Akdis">Mubeccel Akdis</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Bavbek, Sevim" sort="Bavbek, Sevim" uniqKey="Bavbek S" first="Sevim" last="Bavbek">Sevim Bavbek</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University, School of Medicine, Department of Chest Disease, Division of Immunology and Allergy, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University, School of Medicine, Department of Chest Disease, Division of Immunology and Allergy, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Bossios, Apostolos" sort="Bossios, Apostolos" uniqKey="Bossios A" first="Apostolos" last="Bossios">Apostolos Bossios</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Centre for Allergy Research, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet (allergologue)</name><affiliation wicri:level="3"><nlm:affiliation>Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and , Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Charité, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and , Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName><placeName><settlement type="city">Montpellier</settlement><region type="old region" nuts="2">Languedoc-Roussillon</region><region type="region" nuts="2">Occitanie (région administrative)</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire de Montpellier</orgName><orgName type="institution">Université de Montpellier</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><placeName><settlement type="city">Montpellier</settlement><region type="old region" nuts="2">Languedoc-Roussillon</region><region type="region" nuts="2">Occitanie (région administrative)</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire de Montpellier</orgName><orgName type="institution">Université de Montpellier</orgName></affiliation></author><author><name sortKey="Boyman, Onur" sort="Boyman, Onur" uniqKey="Boyman O" first="Onur" last="Boyman">Onur Boyman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Immunology, University Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Chaker, Adam M" sort="Chaker, Adam M" uniqKey="Chaker A" first="Adam M" last="Chaker">Adam M. Chaker</name><affiliation wicri:level="4"><nlm:affiliation>Technical University of Munich, TUM School of Medicine, Klinikumrechts der Isar, Department of Otolaryngology and Center for Allergy and Environment, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technical University of Munich, TUM School of Medicine, Klinikumrechts der Isar, Department of Otolaryngology and Center for Allergy and Environment, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Chan, Susan" sort="Chan, Susan" uniqKey="Chan S" first="Susan" last="Chan">Susan Chan</name><affiliation wicri:level="3"><nlm:affiliation>Guy's and St, Thomas' NHS Foundation Trust, Westminster Bridge Road, London, United KingdomKing's, College LondonSchool of Life Course Sciences & School of Immunology & Microbial Sciences, King's Health Partners, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy's and St, Thomas' NHS Foundation Trust, Westminster Bridge Road, London, United KingdomKing's, College LondonSchool of Life Course Sciences & School of Immunology & Microbial Sciences, King's Health Partners, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatzipetrou, Alexia" sort="Chatzipetrou, Alexia" uniqKey="Chatzipetrou A" first="Alexia" last="Chatzipetrou">Alexia Chatzipetrou</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit 2, nd Department of Dermatology and Venereology, National University of Athens, Medical School, University General Hospital 'ATTIKON", Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Allergy Unit 2, nd Department of Dermatology and Venereology, National University of Athens, Medical School, University General Hospital 'ATTIKON", Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Feleszko, Wojciech" sort="Feleszko, Wojciech" uniqKey="Feleszko W" first="Wojciech" last="Feleszko">Wojciech Feleszko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Firinu, Davide" sort="Firinu, Davide" uniqKey="Firinu D" first="Davide" last="Firinu">Davide Firinu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences and Public Health, University of Cagliari, Monserrato</wicri:regionArea><wicri:noRegion>Monserrato</wicri:noRegion></affiliation></author><author><name sortKey="Jutel, Marek" sort="Jutel, Marek" uniqKey="Jutel M" first="Marek" last="Jutel">Marek Jutel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Wroclaw Medical University, ALL-MED Medical Research Institute, Wrocław, Poland, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, Wroclaw Medical University, ALL-MED Medical Research Institute, Wrocław, Poland, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Kauppi, Paula" sort="Kauppi, Paula" uniqKey="Kauppi P" first="Paula" last="Kauppi">Paula Kauppi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Klimek, Ludger" sort="Klimek, Ludger" uniqKey="Klimek L" first="Ludger" last="Klimek">Ludger Klimek</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Rhinology and Allergy, Wiesbaden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Rhinology and Allergy, Wiesbaden</wicri:regionArea><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion></affiliation></author><author><name sortKey="Kolios, Antonios" sort="Kolios, Antonios" uniqKey="Kolios A" first="Antonios" last="Kolios">Antonios Kolios</name><affiliation wicri:level="3"><nlm:affiliation>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Immunology, University Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kothari, Akash" sort="Kothari, Akash" uniqKey="Kothari A" first="Akash" last="Kothari">Akash Kothari</name><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kowalski, Marek L" sort="Kowalski, Marek L" uniqKey="Kowalski M" first="Marek L" last="Kowalski">Marek L. Kowalski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Immunology and Allergy, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Matucci, Andrea" sort="Matucci, Andrea" uniqKey="Matucci A" first="Andrea" last="Matucci">Andrea Matucci</name><affiliation wicri:level="1"><nlm:affiliation>Immunoallergology Unit, Careggi University Hospital, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Immunoallergology Unit, Careggi University Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palomares, Oscar" sort="Palomares, Oscar" uniqKey="Palomares O" first="Oscar" last="Palomares">Oscar Palomares</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pfaar, Oliver" sort="Pfaar, Oliver" uniqKey="Pfaar O" first="Oliver" last="Pfaar">Oliver Pfaar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Rogala, Barbara" sort="Rogala, Barbara" uniqKey="Rogala B" first="Barbara" last="Rogala">Barbara Rogala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Untersmayr, Eva" sort="Untersmayr, Eva" uniqKey="Untersmayr E" first="Eva" last="Untersmayr">Eva Untersmayr</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Eiwegger, Thomas" sort="Eiwegger, Thomas" uniqKey="Eiwegger T" first="Thomas" last="Eiwegger">Thomas Eiwegger</name><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Immunology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Allergy</title><idno type="eISSN">1398-9995</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a "cytokine storm" and associated organ damage characterized by an exaggerated release of proinflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19 with studies focusing on severe allergic phenotypes lacking. At present, non-infected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management is demanded.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32500526</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1398-9995</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jun</Month><Day>05</Day></PubDate></JournalIssue><Title>Allergy</Title><ISOAbbreviation>Allergy</ISOAbbreviation></Journal><ArticleTitle>Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/all.14407</ELocationID><Abstract><AbstractText>The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a "cytokine storm" and associated organ damage characterized by an exaggerated release of proinflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19 with studies focusing on severe allergic phenotypes lacking. At present, non-infected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management is demanded.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vultaggio</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Immunoallergology Unit, Careggi University Hospital, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agache</LastName><ForeName>Ioana</ForeName><Initials>I</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7994-364X</Identifier><AffiliationInfo><Affiliation>Transylvania University, Brasov, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akdis</LastName><ForeName>Cezmi A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akdis</LastName><ForeName>Mubeccel</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0554-9943</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bavbek</LastName><ForeName>Sevim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Ankara University, School of Medicine, Department of Chest Disease, Division of Immunology and Allergy, Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bossios</LastName><ForeName>Apostolos</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0494-2690</Identifier><AffiliationInfo><Affiliation>Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bousquet</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and , Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Charité, Berlin, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyman</LastName><ForeName>Onur</ForeName><Initials>O</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8279-5545</Identifier><AffiliationInfo><Affiliation>Department of Immunology, University Hospital Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaker</LastName><ForeName>Adam M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Technical University of Munich, TUM School of Medicine, Klinikumrechts der Isar, Department of Otolaryngology and Center for Allergy and Environment, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Guy's and St, Thomas' NHS Foundation Trust, Westminster Bridge Road, London, United KingdomKing's, College LondonSchool of Life Course Sciences & School of Immunology & Microbial Sciences, King's Health Partners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatzipetrou</LastName><ForeName>Alexia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Allergy Unit 2, nd Department of Dermatology and Venereology, National University of Athens, Medical School, University General Hospital 'ATTIKON", Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feleszko</LastName><ForeName>Wojciech</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Firinu</LastName><ForeName>Davide</ForeName><Initials>D</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-5768-391X</Identifier><AffiliationInfo><Affiliation>Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jutel</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, Wroclaw Medical University, ALL-MED Medical Research Institute, Wrocław, Poland, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kauppi</LastName><ForeName>Paula</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klimek</LastName><ForeName>Ludger</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Rhinology and Allergy, Wiesbaden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolios</LastName><ForeName>Antonios</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>MACVIA-France, Montpellier, and CHU Monpellier, Montpellier, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, University Hospital Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kothari</LastName><ForeName>Akash</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1980-161X</Identifier><AffiliationInfo><Affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kowalski</LastName><ForeName>Marek L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matucci</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Immunoallergology Unit, Careggi University Hospital, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palomares</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4516-0369</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfaar</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4374-9639</Identifier><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rogala</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3077-0271</Identifier><AffiliationInfo><Affiliation>Department of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Untersmayr</LastName><ForeName>Eva</ForeName><Initials>E</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1963-499X</Identifier><AffiliationInfo><Affiliation>Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eiwegger</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2914-7829</Identifier><AffiliationInfo><Affiliation>Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Allergy</MedlineTA><NlmUniqueID>7804028</NlmUniqueID><ISSNLinking>0105-4538</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32500526</ArticleId><ArticleId IdType="doi">10.1111/all.14407</ArticleId><ArticleId IdType="pmc">PMC7300800</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>Turquie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Bavière</li><li>Berlin</li><li>Canton de Zurich</li><li>Communauté de Madrid</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Hesse (Land)</li><li>Languedoc-Roussillon</li><li>Massachusetts</li><li>Occitanie (région administrative)</li><li>Ontario</li><li>Svealand</li><li>Vienne (Autriche)</li></region><settlement><li>Athènes</li><li>Berlin</li><li>Londres</li><li>Madrid</li><li>Marbourg</li><li>Montpellier</li><li>Munich</li><li>Stockholm</li><li>Toronto</li><li>Vienne (Autriche)</li><li>Zurich</li></settlement><orgName><li>Centre hospitalier universitaire de Montpellier</li><li>Université Louis-et-Maximilien de Munich</li><li>Université de Montpellier</li><li>Université de Toronto</li><li>Université de Zurich</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Vultaggio, Alessandra" sort="Vultaggio, Alessandra" uniqKey="Vultaggio A" first="Alessandra" last="Vultaggio">Alessandra Vultaggio</name></noRegion><name sortKey="Firinu, Davide" sort="Firinu, Davide" uniqKey="Firinu D" first="Davide" last="Firinu">Davide Firinu</name><name sortKey="Matucci, Andrea" sort="Matucci, Andrea" uniqKey="Matucci A" first="Andrea" last="Matucci">Andrea Matucci</name></country><country name="Roumanie"><noRegion><name sortKey="Agache, Ioana" sort="Agache, Ioana" uniqKey="Agache I" first="Ioana" last="Agache">Ioana Agache</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Akdis, Cezmi A" sort="Akdis, Cezmi A" uniqKey="Akdis C" first="Cezmi A" last="Akdis">Cezmi A. Akdis</name></noRegion><name sortKey="Akdis, Mubeccel" sort="Akdis, Mubeccel" uniqKey="Akdis M" first="Mubeccel" last="Akdis">Mubeccel Akdis</name><name sortKey="Boyman, Onur" sort="Boyman, Onur" uniqKey="Boyman O" first="Onur" last="Boyman">Onur Boyman</name><name sortKey="Boyman, Onur" sort="Boyman, Onur" uniqKey="Boyman O" first="Onur" last="Boyman">Onur Boyman</name><name sortKey="Kolios, Antonios" sort="Kolios, Antonios" uniqKey="Kolios A" first="Antonios" last="Kolios">Antonios Kolios</name></country><country name="Turquie"><noRegion><name sortKey="Bavbek, Sevim" sort="Bavbek, Sevim" uniqKey="Bavbek S" first="Sevim" last="Bavbek">Sevim Bavbek</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Bossios, Apostolos" sort="Bossios, Apostolos" uniqKey="Bossios A" first="Apostolos" last="Bossios">Apostolos Bossios</name></region><name sortKey="Bossios, Apostolos" sort="Bossios, Apostolos" uniqKey="Bossios A" first="Apostolos" last="Bossios">Apostolos Bossios</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet (allergologue)</name></region><name sortKey="Chaker, Adam M" sort="Chaker, Adam M" uniqKey="Chaker A" first="Adam M" last="Chaker">Adam M. Chaker</name><name sortKey="Klimek, Ludger" sort="Klimek, Ludger" uniqKey="Klimek L" first="Ludger" last="Klimek">Ludger Klimek</name><name sortKey="Pfaar, Oliver" sort="Pfaar, Oliver" uniqKey="Pfaar O" first="Oliver" last="Pfaar">Oliver Pfaar</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Bousquet, Jean" sort="Bousquet, Jean" uniqKey="Bousquet J" first="Jean" last="Bousquet">Jean Bousquet (allergologue)</name></region><name sortKey="Kolios, Antonios" sort="Kolios, Antonios" uniqKey="Kolios A" first="Antonios" last="Kolios">Antonios Kolios</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chan, Susan" sort="Chan, Susan" uniqKey="Chan S" first="Susan" last="Chan">Susan Chan</name></region></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Chatzipetrou, Alexia" sort="Chatzipetrou, Alexia" uniqKey="Chatzipetrou A" first="Alexia" last="Chatzipetrou">Alexia Chatzipetrou</name></region></country><country name="Pologne"><noRegion><name sortKey="Feleszko, Wojciech" sort="Feleszko, Wojciech" uniqKey="Feleszko W" first="Wojciech" last="Feleszko">Wojciech Feleszko</name></noRegion><name sortKey="Jutel, Marek" sort="Jutel, Marek" uniqKey="Jutel M" first="Marek" last="Jutel">Marek Jutel</name><name sortKey="Kowalski, Marek L" sort="Kowalski, Marek L" uniqKey="Kowalski M" first="Marek L" last="Kowalski">Marek L. Kowalski</name><name sortKey="Rogala, Barbara" sort="Rogala, Barbara" uniqKey="Rogala B" first="Barbara" last="Rogala">Barbara Rogala</name></country><country name="Finlande"><noRegion><name sortKey="Kauppi, Paula" sort="Kauppi, Paula" uniqKey="Kauppi P" first="Paula" last="Kauppi">Paula Kauppi</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Kolios, Antonios" sort="Kolios, Antonios" uniqKey="Kolios A" first="Antonios" last="Kolios">Antonios Kolios</name></region></country><country name="Canada"><noRegion><name sortKey="Kothari, Akash" sort="Kothari, Akash" uniqKey="Kothari A" first="Akash" last="Kothari">Akash Kothari</name></noRegion><name sortKey="Eiwegger, Thomas" sort="Eiwegger, Thomas" uniqKey="Eiwegger T" first="Thomas" last="Eiwegger">Thomas Eiwegger</name><name sortKey="Eiwegger, Thomas" sort="Eiwegger, Thomas" uniqKey="Eiwegger T" first="Thomas" last="Eiwegger">Thomas Eiwegger</name><name sortKey="Eiwegger, Thomas" sort="Eiwegger, Thomas" uniqKey="Eiwegger T" first="Thomas" last="Eiwegger">Thomas Eiwegger</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Palomares, Oscar" sort="Palomares, Oscar" uniqKey="Palomares O" first="Oscar" last="Palomares">Oscar Palomares</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Untersmayr, Eva" sort="Untersmayr, Eva" uniqKey="Untersmayr E" first="Eva" last="Untersmayr">Eva Untersmayr</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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